Graduate of Oxford University (D. Phil., 1994). Postdoctoral Fellow, University of Cambridge, (1994-1996). Vice-Chancellor's Postdoctoral Research Fellow, UNSW (1997-1998). Lecturer, Flinders University of South Australia (1998). Appointed Lecturer at UNSW (1999), Senior Lecturer (2002), Associate Professor (2006), Professor (2006). NSW Young Tall Poppy Science Prize (2004), Alexander von Humboldt Fellowship (2005), University of Canterbury Erskine Fellow (2007), Royal Australian Chemical Institute Analytical Chemistry Division Lloyd Smythe Medal (2007). Eureka Prize for Scientific Research (2009). ARC Australian Professorial Fellow (2010). UNSW Scientia Professor (2011). Royal Australian Chemical Institute Electrochemistry Division R.H. Stokes Medal (2011).
Our research group specialises in the molecule level modification of surfaces using self-assembled monolayers, biological molecules and nanomaterials to impart a desired functionality to that surface such as to:
- Selectively detect an analyte - biosensors.
- Allow efficient electrical communication with biological molecules - bioelectronics
- To enable fundamental studies into electron transfer at surfaces - molecules electronics
- Influence biological processes - biomaterials
The group is also part of the Australian Centre for Nanomedicine of which Professor Gooding is one of the three directors. As a result much of our research has a nanomedicine focus where we modify surfaces for diagnostic devices, imaging and biomaterials as well as more fundamental work on electron transfer, catalysis and cell-surface interactions.
There are six main research projects in the group:
- Immunosensors for pesticide detection in environmental analysis (with CSIRO) and for protein biomarkers for biomedical applications (with a US based biosensing company)
- Modified porous silicon photonic crystals for developing cell chips for personalized medicine, toxin detection and nanotoxicology (with Dr. Peter Reece, Physics UNSW and A/Prof Katharina Gaus, Medicine UNSW.
- Nanoparticle based biosensors for ultrasensitive detection for medical diagnostics (with Professor Rose Amal, Chemical Engineering, UNSW and Prof. Hibbert, Chemistry UNSW).
- Silicon quantum dots as biocompatible nanomaterials for biolabelling.
- Understanding electron transfer through a new class of molecular wires (with Professor Michael Paddon-Row, Chemistry UNSW).
- Bioelectronics on silicon surfaces.
Research Group and Outputs
The research group is typically between 20 and 25 people in size with 5 post-docs, 15 or so Ph.D. students and 3-4 honours students and visiting students. We create a supportive environment where all researchers work in teams on related projects with junior researchers being assisted by post-docs and senior Ph.D. students as well as Prof. Gooding. As our research involves a range of techniques all researchers acquire a broad range of skills but typically specialise in one or two techniques. Ph.D. students usually complete within 3½ years with 5-10 research publications. Using our team-oriented approach our research group has published 72 papers within the last five years.
Representative publications are listed below.
- D.J. Williamson, D.M. Owen, J. Rossy, M. Wehrmann, A. Magenau, J.J. Gooding, K. Gaus, Pre-existing LAT clusters do not participate in early T cell signaling events, Nature Immunology 12 655-662 (2011).
- G. Le Saux, A. Magenau, T. Böcking, K. Gaus, J.J. Gooding, The relative importance of topography and RGD ligand density for endothelial cell adhesion, PLOS One 6 e21869 (2011).
- M. Chockalingam, N. Darwish, G. Le Saux, J.J. Gooding, The importance of the Indium Tin Oxide substrate on the quality of self assembled monolayers formed from organophosphonic acids, Langmuir 27 2545-2552 (2011).
- G.Z. Liu, J.Q. Liu, T.P. Davis, J.J. Gooding, Electrochemical Impedance Immunosensor Based on Gold Nanoparticles and Aryldiazonium Salts Functionalized Gold, Interface for the Detection of Antibody, Biosensors Bioelectronics 26 3660-3665 (2011).
- G. Le Saux, S. Ciampi, K. Gaus, J.J. Gooding, Electrochemical Behaviour of Gold Colloidal Alkyl Modified Silicon Surfaces, ACS Appl. Mater. Interfaces, 1 2477-2483 (2009).
- K.A. Kilian, L.M.H. Lai, A. Magenau, S. Cartland, T. Böcking, N. Di Girolamo, M. Gal, K. Gaus, J.J. Gooding, Smart Tissue Culture: In Situ Monitoring of Cellular Secretion With Nanostructured Photonic Crystals, NanoLett 9 2021-2025 (2009).
- G.Z. Liu, M.N. Paddon-Row, J.J. Gooding, Protein Modulation of Electrochemical Signals: Application to Immunobiosensing for Detecting Small Molecules, Chem. Comm. 3870-3872 (2008).
- K.A. Kilian, T. Böcking, K. Gaus, J.J. Gooding, Introducing Distinctly Different Chemical Functionalities onto the Internal and External Surfaces of Mesoporous Materials, Angew. Chem. 47 2697-2699 (2008).
- K.A. Kilian, T. Böcking, K. Gaus, M. Gal, J.J. Gooding, Peptide Modified Optical Filters for Detecting Protease Activity, ACS Nano 1 355-361 (2007).
- S. Ciampi, T. Böcking, K.A. Kilian, M. James, J.B. Harper, J.J. Gooding, Functionalization of Acetylene-Terminated Monolayers on Si(100) Surfaces: A Click Chemistry Approach, Langmuir 23 9320-9329 (2007).