The Harding Group - Publications
Antifreeze Proteins
J. Garner, S. R. Inglis, J. Hook, F. Separovic, and M. M. Harding
A solid-state NMR study of the interaction of fish antifreeze proteins with phospholipid membranes
Eur. J. Biophys., 2008, 37, 1031-1038.
J. Garner and M. M. Harding
Synthetic Mimics of a-Helical Peptides
Org. Biomol. Chem. 2007 5, 3577-3585.
S. R. Inglis, J. J.Turner, and M. M. Harding
Applications of Type I Antifreeze Proteins: Studies with Model Membranes and Cryoprotectant Properties
Curr. Protein Peptide Sci., 2006 7, 509-522.
S. R. Inglis, M.J. McGann, W. S. Price and M. M. Harding
Diffusion NMR Studies on Fish Antifreeze Proteins and Synthetic Analogues
FEBS Letters 2006 580, 3911-3915.
A. Kwan, K. Fairley, P. I. Anderberg, C. W. Liew, M. M. Harding and J. P. Mackay
Solution Structure of a Recombinant Type I Sculpin Antifreeze Protein
Biochemistry 2005 44, 1980-1988.
M. M. Tomczak, D. K. Hincha, J. H. Crowe, M. M. Harding and A. D. J. Haymet
The Effect of Hydrophobic Analogues of the Type I Winter Flounder Antifreeze Protein on Lipid Bilayers
FEBS Letters 2003, 551, 13-19.
M. M. Harding, P. I. Anderberg and A. D. J. Haymet
"Antifreeze" Glycoproteins from Polar Fish
Eur. J. Biochem., 2003, 270, 1381-1392.
K. Fairley, B. J. Westman, L. H. Pham, A. D. J. Haymet, M. M. Harding and J. P. Mackay
Type I Shorthorn Sculpin Antifreeze Protein: Recombinant Synthesis, NMR Spectroscopy & Ice Growth Inhibition Properties
J. Biol. Chem. 2002, 277, 24073-24080.
E. Liepinsh, G. Otting, M. M Harding, L. G. Ward, J. P. Mackay and A. D.J. Haymet
Solution Structure of a Hydrophobic Analogue of the Winter Flounder Antifreeze Protein
Eur. J. Biochem. 2002, 264, 1269-1266.
A.D.J. Haymet, L.G. Ward and M.M. Harding
Hydrophobic Analogues of the Winter Flounder Antifreeze Protein
FEBS Letters, 2001, 491, 285-288.
M. M. Harding, L. G. Ward and A. D. J. Haymet
Type I antifreeze proteins: structure-activity studies and mechanisms of ice growth inhibition
Eur. J. Biochem., 1999, 264, 653-665.
A. D. J. Haymet, L. G. Ward and M. M. Harding
Winter flounder antifreeze proteins: Synthesis and ice growth inhibition of analogues that probe the relative importance of hydrophobic and hydrogen bonding interactions
J. Am. Chem. Soc., 1999, 121, 941-948.
A.D.J. Haymet, L.G. Ward, M. M. Harding and C.A. Knight
Valine Substituted Winter Flounder "Antifreeze": Preservation of Ice Growth Hysteresis
FEBS Letters, 1998, 430, 301-306.
M.M. Harding, L.G. Ward and A.D.J. Haymet
Why Fish Don't Freeze in Polar Waters
Chem. in Aust., 1999, 31-33.
Medicinal Chemistry
Metallocene Dihalides
D. P. Buck, P. M. Abeysinghe, C. Cuneene, A. J. Day, J. G. Collins and M. M. Harding
Inclusion Complexes of the Antitumour Metallocenes Cp2MCl2 (M=Mo, Ti) with Curcurbit[n]urils
Dalton Trans. 2008, 2328 - 2334.
P. M. Abeysinghe and M. M. Harding
Antitumor Bis(cylopentadienyl) Metallocenes: Titanocene and Molybdocene Dichloride and Derivatives
Dalton Trans. 2007, 3474 - 3482; Featured in Chemical Biology, 2007.
K. Campbell, C. T. Dillon, S. V. Smith and M. M. Harding
Radiotracer Studies of the Antitumor Metallocene Molybdocene Dichloride with Biomolecules
Polyhedron 2007, 26, 456-459.
J. B. Waern, P. Turner and M. M. Harding K. Campbell, A. J. Foster, C. T. Dillon and M. M. Harding
Genotoxicity and Transmission Electron Microscopy of Molybdocene Dichloride
J. Inorg. Biochem. 2006, 100, 1194-1198.
J. B. Waern, P. Turner and M. M. Harding
Synthesis and Hydrolysis of Thiol Derivatives of Molybdocene Dichloride Incorporating Electron Withdrawing Substituents
Organometallics 2006, 25, 3417-3421.
K. Campbell, A. J. Foster, C. T. Dillon and M. M. Harding
Genotoxicity and Transmission Electron Microscopy of Molybdocene Dichloride
J. Inorg. Biochem. 2006, 100, 1194-1198.
J. B. Waern, H. Harris, B. Lai, Z. Cai, M. M. Harding and C. T. Dillon
Intracellular Mapping of the Distribution of Metals Derived from the Antitumor Metallocenes
J. Biol. Inorg. Chem. 2005, 10, 443-452.
J. B. Waern, C. T. Dillon and M. M. Harding
Organometallic Anticancer Agents: Cellular Uptake and Cytotoxicity Studies on Thiol Derivatives of the Antitumor Agent Molybdocene Dichloride
J. Med. Chem., 2005, 48, 2093-2099.
J. B. Waern and M. M. Harding
Bioorganometallic Chemistry of Molybdocene Dichloride
J. Organomet. Chem., 2004, 689, 4655-4668.
J. B. Waern and M.M. Harding
Coordination Chemistry of the Antitumor Metallocene Molybdocene Dichloride with Biological Ligands
Inorg. Chem., 2004, 43, 206-213.
G. Mokdsi and M. M. Harding
A 1H NMR Study of the Interaction of Antitumour Metallocenes with Glutathione
J. Inorg. Biochem., 2001, 86, 611-616.
G. Mokdsi and M. M. Harding
Topoisomerase II Inhibition by the Antitumor Metallocenes
J. Inorg. Biochem., 2001, 83, 205-209.
G. Mokdsi and M. M. Harding
Antitumour Metallocenes: Structure-Activity Studies and Interactions with Biomolecules
Curr. Med. Chem., 2000, 7, 1289-1303.
G. Mokdsi and M. M. Harding
Antitumour Metallocenes : Effect of DMSO on the Stability of Cp2TiX2 and Implications for Anticancer Activity
Metal-Based Drugs, 1998, 5, 207-215.
G. Mokdsi and M. M. Harding
Hydrolytically Stable Derivatives of the Antitumour Agent Titanocene Dichloride and Binding Studies with Nucleotides
J. Organomet. Chem., 1998, 565, 29-35.
M.M. Harding , G. Mokdsi, J. Mackay, M. Prodigalidad and S. Lucas
Interaction of the Antitumour Agent Molydocene Dichloride with Oligonucleotides
Inorg. Chem., 1998, 37, 2432-2437.
M.M. Harding , M. Prodigalidad and M.J. Lynch,
Organometallic Anticancer Agents 2: Interaction of Niobocene Dichloride with Nucleic Acid Constituents
J. Med. Chem., 1996, 39, 5012-5016.
J. H. Murray and M. M. Harding,
Organometallic Anticancer Agents: The Effect of the Central Metal and Halide Ligands on the Interaction of Metallocene Dihalides with Nucleic Acid Constituents,
J. Med. Chem., 1994, 37, 1936-1941.
M.M. Harding, G.J. Harden and L.D. Field,
A 31P NMR Study of the Interaction of the Antitumour Active Metallocene MoCp2Cl2 withCalf Thymus DNA,
FEBS Letters, 1993, 3, 291-294.
Streptonigrin
P.I Anderberg, M.M. Harding and P. A. Lay
The Effect of Metal Ions on the Redox Potential of the Antitumour Antibiotic Streptonigrin
J. Inorg. Biochem., 2004, 98, 720-726.
P. I. Anderberg, M. M. Harding, I. J. Luck and P Turner
Ruthenium Complexes of Analogues of the Antitumor Antibiotic Streptonigrin
Inorg. Chem. 2002, 41, 1365-1371.
P. I. Anderberg and M. M. Harding
The Role of Ring D in the Antitumor Antibiotic Streptonigrin. Metal Complexation, DNA Binding and Topoismerase II Inhibition of ABC Analogues of Streptonigrin
Anti-Cancer Drug Design 2001, 16, 143-153.
P. I. Anderberg, M. M. Harding and I. J. Luck
Assignment of the 13C and 15N NMR Spectrum of the Antitumour Antibiotic Streptonigrin
Mag. Reson. Chem. 2002, 40, 313-315.
M. Kimber, P. I. Anderberg and M.M. Harding
Synthesis of ABC Analogues of Streptonigrin
Tetrahedron, 2000, 56, 3575-3581.
G.V. Long and M. M. Harding
Interaction of the Antitumor Antibiotic Streptonigrin with DNA and Metal Ions
Current Medicinal Chemistry, 1997, 4, 385-400.
G. V. Long, M. M. Harding, J. Fan and W. A. Denny
Interaction of the Antitumor Antibiotic Streptonigrin with DNA and Oligonucleotides
AntiCancer Drug Design, 1997, 12, 453-472.
G. V. Long and M. M. Harding
A 1H NMR Study of the Interaction of Zinc(II) with the Antitumor Drug Streptonigrin
J. Chem. Soc., Dalton Trans., 1996, 549-552.
G. V. Long, M. M. Harding, P. Turner and T. W Hambley
Copper(II) Bipyridyl and Aminopyridyl Analogues of Streptonigrin
J. Chem. Soc. Dalton Trans., 1995, 3905-3910.
G. V. Long, M. M. Harding, M. C. L. Xie, I. Buys and T. W Hambley
3-Amino-6,6'-dimethoxycarbonyl-2,2'-bipyridine dimethylester, a Model for the Central Chelation Unit of Streptonigrin
J. Chem. Soc. Dalton Trans., 1995, 951-955.
M.M. Harding, G.V. Long and C.L. Brown
Solution Structure of the Antitumor Drug Streptonigrin
J. Med. Chem., 1993, 36, 3056-3060.
G.V. Long, S.E. Boyd, M.M. Harding, I. Buys and Trevor Hambley
Synthesis, Properties and Coordination Chemistry of 3-Amino-6,6'-dimethyl-2,2'-bipyridine
J. Chem. Soc., Dalton Trans., 1993, 3175-3180.
Anthracyclines
C. J. Shelton, M. M. Harding, and A. S. Prakash,
Enzymatic and Chemical Footprinting of Anthracycline Antitumor Antibiotics and Related Saccharide Side Chains,
Biochemistry, 1996, 24, 7974-7982.
J. Mackay, C. J. Shelton and M. M. Harding,
Assignment of 1H NMR Spectrum and Solution Conformation of the Antitumour Antibiotic Ditrisarubicin B,
Tetrahedron, 1996, 52, 5617-5624.
C. J. Shelton and M. M. Harding,
Synthesis and DNA-Binding of the Methyl α-L-Glycosides of Anthracycline Carbohydrate Sidechains,
J. Chem. Research, 1995, 158.
DNA-Intercalators
A. R. Grummitt and M. M. Harding
9-Hydroxyellipticines and Derivatives as Chemotherapy Agents
Mini-reviews in Medicinal Chemistry 2003, 3, 67-76.
A. R. Grummit, M. M. Harding, P. I. Anderberg and A. Rodger
Carbohydrate Derivatives of the Antitumour Alkaloid 9-Hydroxyellipticine
Eur. J. Org. Chem., 2003, 63-71.
M. M. Harding, G. Y. Krippner, A. Rodger, K. J. Sanders, J. Mackay, A. S. Prakash and C. J. Shelton
DNA-Binding Studies of XSPTSPSZ, Derivatives of the Intercalating Heptad Repeat of RNA Polymerase II
Biopolymers, 1997, 42, 387-398.
C.L. Brown, M.M. Harding, G. Y. Krippner, S. Rainone and L. K. Webster,
Preparation and Biological Activity of Heteroaryl Substituted Bile Steroids,
Aust. J. Chem., 1996, 49, 7-11.
G. Y. Krippner and M.M. Harding
Intercalator Amino Acids. Synthesis of Heteroaryl Alanines
Tetrahedron Asymmetry, 1994, 5, 1793-1804.
C.L. Brown, M.M. Harding, J.R. Kalman, C. Marjo, S. Rainone and L. K. Webster,
Synthesis and Biological Activity of Intercalator Substituted Bile Steroids,
Bioorg. & Med. Chem. Lett., 1994, 4, 1253-1256.
C.L. Brown and M.M. Harding,
Synthetic Alpha-Helical Peptides Containing Intercalators for DNA Recognition
J. Mol. Recognit., 1994, 7, 215-220.
M.M. Harding
NMR Studies on YSPTSPSY: Implications for the Design of DNA-Bisintercalators
J. Med. Chem., 1992, 35, 4658-64.
Supramolecular Chemistry
C. K. Y. Lee, J. Groneman, P. Turner, L. M. Rendina and M. M. Harding
Synthesis and X-Ray Crystallographic Analysis of Chiral Pyridyl Substituted Carbocyclic Molecular Clefts
Tetrahedron 2006, 62, 4870-4878.
J. J. Turner and M. M. Harding
Synthesis and Properties of Chiral Molecular Clefts Related to Tröger's Base
Supramol. Chem. 2005, 17, 369-375.
P. I. Anderberg, J. Turner, K. J. Evans, L. M. Hutchins and M. M. Harding
Ligand self-recognition in the stereoselective assmebly of [2+2] metallomacrocycles from racemic chiral bipyridyl molecular clefts and zinc(II)
J. Chem. Soc. Dalton Trans., 2004, 1708-1714.
J. D. Field, P. Turner, M. M. Harding, T. Hatzikominos and L. Kim
Chiral Carbocyclic Molecular Clefts Incorporating Hydrogen Bonding Features
New J. Chem. 2002, 26, 720-725.
M. C. Kimber, A. C. Try, L. Painter, M. M. Harding and P. Turner
Synthesis of Functionalised Chiral Carbocyclic Cleft Molecules Complementary to Trogers Base Derivatives
J. Org. Chem., 2000, 65, 3042-3046.
A. C. Try, L. Painter and M. M. Harding
Rigid Chiral Carbocyclic Clefts as Building Blocks for the Construction of New Supramolecular Hosts
Tetrahedron Letters, 1998, 9809-9812.
A. C. Try, M. M. Harding, D. G. Hamilton and J. K. M. Sanders
Reversible five component assembly of a [2]catenane from a chiral metallomacrocycle and a dinaphtho-crown ether
J. Chem. Soc. Chem. Commun., 1998, 723-724.
M. A. Houghton, A. Bilyk and M. M. Harding, P. Turner and T. W. Hambley
Effect of Guest Molecules, Metal Ions and Linker Length on the Assembly of Chiral [2+2] Metallomacrocyles: Solution Studies and X-ray Crystal Structures
J. Chem. Soc. Dalton Trans, 1997, 2725-2733.
A. Bilyk and M.M. Harding
Guest Induced Assembly of a Chiral [2+2] Metallomacrocyle
J. Chem. Soc. Dalton Trans, 1995, 1697-1698.
A. Bilyk, M.M. Harding, P. Turner and T. W. Hambley
Octahedral Non-helical Bispypyridyl Metallomacrocyles
J. Chem. Soc. Dalton Trans, 1995, 2549-2553.
A. Bilyk, M.M. Harding, P. Turner and T. W. Hambley
Factors Affecting the Assembly of Helical and Non-helical Metallomacrocycles
J. Chem. Soc. Dalton Trans, 1994, 2783-2790.
A. Bilyk and M.M. Harding
Assembly of Macrocycles from Bisbipyridyl Ligands and Metal Ions
J. Chem. Soc. Dalton Trans, 1994, 77-82.
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